Life Extension believes that there are physiological and psychological benefits to using orlistat at least on a temporary basis. By combining orlistat with a comprehensive weight management program, more fat pounds will be shed from the body, thus providing the physiological effect. A psychological benefit is seeing undigested fat being passed naturally from the body.

Those embarking on a weight-loss program expect to see relatively rapid results. While orlistat has yielded only modest effects by itself, its unique mechanism of blocking 30% of dietary fat from being absorbed provides an important weapon in a comprehensive fat-loss armamentarium.

In order to maintain optimal nutritional status while taking alli® or other compounds that impede fat absorption, it is of paramount importance that you supplement each day with fat-soluble nutrients such as vitamins D, K, and omega-3. Since fat normally shuttles these nutrients into the bloodstream, you should also take them at a time of day that ensures maximum absorption.

Life Extension® now offers a simple one-per-day capsule to meet this critical need. The new Essential Fat-Soluble Nutrients formula supplies an array of key nutrients in amounts that help to offset the potential for nutritional insufficiency. Taking one softgel at least 4 hours before or after using lipase inhibitors (or other compounds that impede fat digestion) will help maintain a healthy nutritional profile as you safely induce weight loss.

alli® is a registered trademark of GlaxoSmithKline LLC.

Individuals consuming more than 2,000 IU/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10,000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with hypercalcemia (high blood calcium levels). People with kidney disease, certain medical conditions (such as hyperparathyroidism or sarcoidosis), and those who use cardiac glycosides (digoxin) or thiazide diuretics should consult a physician before using supplemental vitamin D. If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult with your healthcare practitioner before taking this product.